Cannabis Working With Opioids To Fight Pain


There is plenty of evidence that in places where cannabis is legal the amount of opioid-related deaths plummets. Mostly it’s been thought that this is due to those with chronic pain replacing their pharmaceutical medications with cannabis use, but a recent study has found that using low doses of opioids with cannabis can have the same effect as using higher doses of opioids together.

The research, published in the journal Neuropsychopharmacology has found through clinical trial data that cannabis used alongside “subtherapeutic doses” (lower doses than what normally would be effective) of oxycodone relieved pain at the same level of a higher dose of oxycodone.




The study was conducted by researchers from the United States and Australia. It was a placebo-controlled, double-blind study that included three groups: one that was given cannabis, one given oxycodone, and one given a combination of both. The two substances were found to work synergistically together.

According to the research “Both active cannabis and a low dose of oxycodone (2.5 mg) were sub-therapeutic, failing to elicit analgesia on their own, however, when administered together, pain response were significantly reduced, pointing to the opioid-sparing effects of cannabis.”

Patients currently on high doses of opioids could benefit from this information by lowering the amount of dangerous medications they are on and use cannabis as a way to achieve the same results.

March 14, 2018

by Shasta Nelson

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Shasta Nelson is a California Native and a cannabis connoisseur. She's been involved in the industry at every level since she was a teenager. Currently she provides content for Roottie, DOPE Magazine, and Terpenes and Testing. She's also a creative writer, with a graphic novel underway.


  • shisoshin

    this is no surprise given human brain endo-cannabinoid system..
    this important system in everones brain uses cbd’s produced by the body and used by endo-cannabinoid system therapeutically including relative to pain, seizure events, cell apoptosis [cells ‘death switch’ influenced by cancer to continue cell life – thus life of cancer –
    therefore actively anti-cancer] and other therapeutic or ‘healing’ effects and interactions, important given todays understandings of brain plasticity or ability to heal – once thought impossible – which also invluences some damage induced or brain scarring epilepsy etc]..

    we should all be or become familiar with our and all human brains’ endo-cannabinoid system,, which also makes use of plant based cbd’s
    such as important elements of cannabis sativa..

    for old brains conditioned to believe cannabis a tool of the devil etc, todays understandings of our endo-cannabinoid systems changes that false and wrong idea,, to more like a ‘gift from god’..
    it is a question as response to anyone who tries to present negative arguments about cannabis as a solely psychotropic drug..

    [i have personally been cured,, of temporal lobe brand mal epilepsy,
    thru use of fresh mainly home grown cannabis, after a prognosis of
    ‘institutionalised by 55’ from my neurologist using conventional anti epileptic medication.. today i am fit free, not even a headache, over 20 yrs, and approaching 70.. due to wonderful cannabis dbd’s]

    like all drugs,, dose is fundamentally important..
    many users overdose, based on ignorance of doseage..
    compare taking a nip of whiskey to half a bottle..

    those who dont know, are conditioned to reefer madness etc,
    observe people stoned off their faces form overdosing cannabis
    thu high thc [also potentially therapeutic] – then know for a fact
    that cannabis is ‘bad’ like watching bombed out drunks..

    this level of information as to cannabis together with opioids
    thus providing endo-cannabinoid system with more options
    to manage pain etc,, is vital to ongoing cannabis law reforms..
    so thanks to researchers and journalists presenting this good
    news to us and thus to general ‘news’ and public consciousness..

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