Phytocannabinoids are the fuel to the cannabis plant’s fire, producing almost all of the lovely, happy, giggly, munchy effects we’ve come to love. On top of this, phytocannabinoids are also unique and potent medicines in a number of weird and wonderful ways. They’re lipophilic, meaning they’re attracted to fats and repelled by water, which makes transport a bit trickier in the body. They tend to have very different effects depending on the dose, many producing opposite effects at high and low doses. And finally, phytocannabinoids don’t just activate one receptor or even keep their interactions within one system! They bind to a number of molecular targets, including neurotransmitter sites, ion channels, and enzymes, all of which contribute to the cannabis plant’s “promiscuous pharmacology.”
THCV is one of these quirky compounds. Depending on the dose and the method of administration, THCV can have wildly different effects. (Although it’s important to note that most of our knowledge can be attributed to the limited number of studies that have only begun to fill in the picture.) Studies suggest that the different effects stem from the compound’s unique cannabinoid receptor interactions. At low to mid doses, THCV seems to act as a potent CB1 receptor antagonist, interfering with binding at the CB1 receptor and reducing the effects of THC. However, at high to very high doses, THCV is a potent agonist, with effects reported to be profoundly energetic, clear-headed, and euphoric. It’s speculated that THCV levels play a role in the cerebral and “zippy” experiences when using tropical Asian and African landrace strains, which have been found to exhibit high levels of the compound—up to 53.7% of the total cannabinoid content!
The doses used for medical purposes are typically too low to produce psychoactive effects. Doses in this range have shown enough promise to prompt GW pharmaceuticals to take out an active research patent investigating THCV in the treatment of conditions ranging from Alzheimer’s to addiction and diabetes. All in all, THCV seems to indicate the following:
While it might not be the next new diet craze, THCV presents a novel tool for people seeking a less munchy and more focused stone. And on top of that, it could be a valuable tool in the fight against diabetes, neurological disease, and so much more.Posted: Tuesday, September 25th, 10:00am 3 months ago
Lana Tong is an aspiring Biochemist and Squirrel Behavioral Psychologist based in Victoria, British Columbia. She's passionate about cannabis as a medicine, entheogen, food, fiber crop, and so much more. Lana hopes to one day swim in a pool filled with organic CBD oil. We all have dreams - right?!